Research workbench
Human VPS33A
Analyse Human VPS33A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BX8
- Type
- protein
- Length
- 1,138 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vacuolar protein sorting-associated protein 33A
- UniProt
- Q96AX1
- Ligands
- CL
- Pockets
- 18 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vacuolar protein sorting-associated protein 33A | protein | 568 | 49% helix, 16% strand | Q96AX1 |
| B | Vacuolar protein sorting-associated protein 33A | protein | 570 | 48% helix, 16% strand | Q96AX1 |
Ligands and binding sites
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 767 | 0.75 | 0.80 | 79 | empty |
| 2 | 455 | 0.74 | 0.83 | 46 | empty |
| 3 | 618 | 0.68 | 0.77 | 76 | empty |
| 4 | 274 | 0.66 | 0.82 | 36 | empty |
| 5 | 212 | 0.62 | 0.82 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1289 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96AX1
- Elsewhere: RCSB PDB 4BX8 · PDBe 4BX8 · UniProt Q96AX1
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