Research workbench
Structure of wild type PHAZ7 phb depolymerase
Analyse Structure of wild type PHAZ7 phb depolymerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BRS
- Type
- protein
- Length
- 674 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phb depolymerase PHAZ7
- EC
- 3.1.1.75
- UniProt
- Q939Q9
- Ligands
- NA, MG, CL
- Pockets
- 4 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phb depolymerase PHAZ7 (EC 3.1.1.75) | protein | 342 | 27% helix, 16% strand | Q939Q9 |
| B | Phb depolymerase PHAZ7 (EC 3.1.1.75) | protein | 332 | 29% helix, 17% strand | Q939Q9 |
Ligands and binding sites
- NA · Sodium ion · metal · 3 copies · chains A, B
- MG · Magnesium ion · metal · chains A
- CL · Chloride ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 246 | 0.55 | 0.77 | 41 | empty |
| 2 | 146 | 0.42 | 0.75 | 30 | empty |
| 3 | 69 | 0.34 | 0.76 | 18 | empty |
| 4 | 53 | 0.28 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 256 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 4BRS · Structure of wild type PhaZ7 PHB depolymerase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q939Q9
- Elsewhere: RCSB PDB 4BRS · PDBe 4BRS · UniProt Q939Q9
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