Research workbench
PACSIN2 interacts with membranes and actin-filaments
Analyse PACSIN2 interacts with membranes and actin-filaments in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BNE
- Type
- protein
- Length
- 579 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase C and casein kinase substrate in neurons protein 2
- UniProt
- O13154
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 82% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase C and casein kinase substrate in neurons protein 2 | protein | 290 | 81% helix, 1% strand | O13154 |
| B | Protein kinase C and casein kinase substrate in neurons protein 2 | protein | 289 | 82% helix, 1% strand | O13154 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 7 copies · chains A, B
- PGE · Triethylene glycol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 158 | 0.55 | 0.81 | 19 | empty |
| 2 | 156 | 0.55 | 0.81 | 19 | empty |
| 3 | 50 | 0.32 | 0.77 | 8 | PGE |
| 4 | 64 | 0.32 | 0.75 | 12 | PGE |
Interfaces
1 interface between chains.
- A–B · 4768 Ų buried · 51 hydrogen bonds · protein-protein
Compared structures
- 4BNE · Pacsin2 Interacts with Membranes and Actin-Filaments · the same entry in another collection · chain A against A, TM-score 1.00
- O13154 · AlphaFold monomer V2.0 prediction for protein kinase C and casein kinase substrate in… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O13154
- Elsewhere: RCSB PDB 4BNE · PDBe 4BNE · UniProt O13154
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