Research workbench
Structure of futalosine hydrolase mutant of helicobacter pylori strain 26695
Analyse Structure of futalosine hydrolase mutant of helicobacter pylori strain 26695 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BN0
- Type
- protein
- Length
- 889 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MTA/SAH nucleosidase
- EC
- 3.2.2.9
- UniProt
- O24915
- Pockets
- 12 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 36% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MTA/SAH nucleosidase (EC 3.2.2.9) | protein | 225 | 38% helix, 30% strand | O24915 |
| B, D | MTA/SAH nucleosidase (EC 3.2.2.9) | protein | 223 | 35% helix, 31% strand | O24915 |
| C | MTA/SAH nucleosidase (EC 3.2.2.9) | protein | 218 | 35% helix, 31% strand | O24915 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 221 | 0.65 | 0.83 | 29 | empty |
| 2 | 321 | 0.65 | 0.80 | 39 | empty |
| 3 | 238 | 0.63 | 0.81 | 28 | empty |
| 4 | 177 | 0.51 | 0.77 | 26 | empty |
| 5 | 135 | 0.48 | 0.79 | 21 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1615 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1569 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 370 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 357 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 316 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4BN0 · Structure of futalosine hydrolase mutant of Helicobacter pylori strain 26695 · the same entry in another collection · chain A against A, TM-score 1.00
- O24915 · AlphaFold monomer V2.0 prediction for aminodeoxyfutalosine nucleosidase (O24915) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O24915
- Elsewhere: RCSB PDB 4BN0 · PDBe 4BN0 · UniProt O24915
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