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Crystal structure of mhv-68 latency-associated nuclear antigen (lana) C-terminal DNA binding domain

Analyse Crystal structure of mhv-68 latency-associated nuclear antigen (lana)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4BLG
Type: protein
Length: 240 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Latency-associated nuclear antigen
UniProt: O41974
Ligands: PO4
Pockets: 1 · best druggability 0.25

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Latency-associated nuclear antigen	protein	121	35% helix, 21% strand	O41974
B	Latency-associated nuclear antigen	protein	119	32% helix, 22% strand	O41974

Ligands and binding sites

PO4 · Phosphate ion · ion · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.25	0.73	12	empty

Interfaces

1 interface between chains.

A–B · 1445 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4BLG · Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O41974
Elsewhere: RCSB PDB 4BLG · PDBe 4BLG · UniProt O41974

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