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Human dihydropyrimidinase-related protein 3 (DPYSL3)

Analyse Human dihydropyrimidinase-related protein 3 (DPYSL3) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4BKN
Type: protein
Length: 962 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dihydropyrimidinase-related protein 3
UniProt: Q14195
Pockets: 9 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dihydropyrimidinase-related protein 3	protein	480	36% helix, 24% strand	Q14195
B	Dihydropyrimidinase-related protein 3	protein	482	36% helix, 24% strand	Q14195

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	908	0.84	0.86	77	empty
2	295	0.70	0.84	48	empty
3	346	0.70	0.82	49	empty
4	147	0.58	0.83	21	empty
5	155	0.57	0.82	22	empty

Interfaces

1 interface between chains.

A–B · 1154 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

4BKN · Human Dihydropyrimidinase-related protein 3 (DPYSL3) · the same entry in another collection · chain A against A, TM-score 1.00
Q14195 · AlphaFold monomer V2.0 prediction for dihydropyrimidinase-related protein 3 (Q14195) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14195
Elsewhere: RCSB PDB 4BKN · PDBe 4BKN · UniProt Q14195

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