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Locw, a lambda 1 type light-chain dimer (bence-jones protein) crystallized in distilled water

Analyse Locw, a lambda 1 type light-chain dimer (bence-jones protein) crystallized in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4BJL
Type: protein
Length: 432 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Loc - lambda 1 type light-chain dimer
Pockets: 5 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Loc - lambda 1 type light-chain dimer	protein	216	6% helix, 44% strand	—

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	407	0.65	0.78	52	empty
2	150	0.56	0.81	33	empty
3	376	0.53	0.73	41	empty
4	108	0.42	0.76	18	empty
5	52	0.25	0.73	17	empty

Interfaces

1 interface between chains.

A–B · 1728 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide, 2 modified (disulfide, cyclization).

Compared structures

4BJL · Locw, a lambda 1 type light-chain dimer (bence-jones protein) crystallized in distilled… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4BJL · PDBe 4BJL

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