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Structure of pseudomonas aeruginosa amidase AMPDH2

Analyse Structure of pseudomonas aeruginosa amidase AMPDH2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4BJ4
Type: protein
Length: 492 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: AMPDH2
EC: 3.5.1.28
UniProt: Q9HT86
Pockets: 8 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	AMPDH2 (EC 3.5.1.28)	protein	246	35% helix, 16% strand	Q9HT86

Ligands and binding sites

FLC · Citrate anion · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.48	0.84	26	empty
2	65	0.36	0.78	15	empty
3	85	0.35	0.75	22	empty
4	66	0.34	0.77	17	empty
5	79	0.31	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 2174 Å² buried · 48 hydrogen bonds · protein-protein

Compared structures

4BJ4 · Structure of Pseudomonas aeruginosa amidase Ampdh2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HT86
Elsewhere: RCSB PDB 4BJ4 · PDBe 4BJ4 · UniProt Q9HT86

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