Research workbench
Cryo-EM structure of the navct voltage-gated sodium channel
Analyse Cryo-EM structure of the navct voltage-gated sodium channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BGN
- Type
- protein
- Length
- 424 residues
- Chains
- 2
- Method
- electron crystallography
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated sodium channel
- UniProt
- F5L478
- Pockets
- 3 · best druggability 0.49
Structure
electron crystallography · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-gated sodium channel | protein | 213 | 82% helix, 0% strand | F5L478 |
| B | Voltage-gated sodium channel | protein | 211 | 77% helix, 0% strand | F5L478 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.49 | 0.79 | 20 | empty |
| 2 | 115 | 0.44 | 0.78 | 21 | empty |
| 3 | 59 | 0.29 | 0.74 | 15 | empty |
Compared structures
- 4BGN · cryo-EM structure of the NavCt voltage-gated sodium channel · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F5L478
- Elsewhere: RCSB PDB 4BGN · PDBe 4BGN · UniProt F5L478
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