Research workbench
Structure of HDCP1A in complex with proline rich sequence of PNRC2
Analyse Structure of HDCP1A in complex with proline rich sequence of PNRC2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4B6H
- Type
- protein
- Length
- 256 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MRNA-decapping enzyme 1A; Proline-rich nuclear receptor coactivator 2
- EC
- 3.-.-.-
- UniProt
- Q9NPI6, Q9NPJ4
- Pockets
- 2 · best druggability 0.37
Structure
x-ray diffraction · 4 distinct chains · 21% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MRNA-decapping enzyme 1A (EC 3.-.-.-) | protein | 129 | 26% helix, 47% strand | Q9NPI6 |
| B | MRNA-decapping enzyme 1A (EC 3.-.-.-) | protein | 100 | 13% helix, 54% strand | Q9NPI6 |
| C | Proline-rich nuclear receptor coactivator 2 | protein | 14 | 21% helix, 0% strand | Q9NPJ4 |
| D | Proline-rich nuclear receptor coactivator 2 | protein | 13 | 23% helix, 0% strand | Q9NPJ4 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.37 | 0.75 | 23 | empty |
| 2 | 68 | 0.35 | 0.76 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–C · 733 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 669 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 361 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4B6H · Structure of hDcp1a in complex with proline rich sequence of PNRC2 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9NPI6 · AlphaFold monomer V2.0 prediction for mRNA-decapping enzyme 1A (Q9NPI6) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q9NPJ4 · AlphaFold monomer V2.0 prediction for proline-rich nuclear receptor coactivator 2 (Q9NPJ4) · a predicted model of the same protein · chain D against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NPI6
- Every structure of UniProt Q9NPJ4
- Elsewhere: RCSB PDB 4B6H · PDBe 4B6H · UniProt Q9NPI6 · UniProt Q9NPJ4
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