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Structure of the human collapsin response mediator protein-1, a lung cancer suppressor
Analyse Structure of the human collapsin response mediator protein-1, a lung cancer… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4B3Z
- Type
- protein
- Length
- 1,890 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydropyrimidinase-related protein 1
- UniProt
- Q14194
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 4 distinct chains · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydropyrimidinase-related protein 1 | protein | 476 | 37% helix, 24% strand | Q14194 |
| B | Dihydropyrimidinase-related protein 1 | protein | 469 | 36% helix, 24% strand | Q14194 |
| C | Dihydropyrimidinase-related protein 1 | protein | 468 | 37% helix, 23% strand | Q14194 |
| D | Dihydropyrimidinase-related protein 1 | protein | 477 | 36% helix, 23% strand | Q14194 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 821 | 0.87 | 0.89 | 87 | empty |
| 2 | 795 | 0.86 | 0.90 | 73 | empty |
| 3 | 1122 | 0.83 | 0.84 | 141 | empty |
| 4 | 61 | 0.70 | 0.97 | 29 | empty |
| 5 | 259 | 0.56 | 0.77 | 27 | empty |
Interfaces
6 interfaces between chains.
- B–D · 1481 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 1368 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 1303 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 1233 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 31 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4B3Z · Structure of the human collapsin response mediator protein-1, a lung cancer suppressor · the same entry in another collection · chain D against D, TM-score 1.00
- Q14194 · AlphaFold monomer V2.0 prediction for dihydropyrimidinase-related protein 1 (Q14194) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14194
- Elsewhere: RCSB PDB 4B3Z · PDBe 4B3Z · UniProt Q14194
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