Research workbench
Complex of the CAF1AN usher domain, CAF1M chaperone and CAF1 subunit from yersinia pestis
Analyse Complex of the CAF1AN usher domain, CAF1M chaperone and CAF1 subunit from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4B0M
- Type
- protein
- Length
- 478 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F1 capsule-anchoring protein; F1 capsule antigen; Chaperone protein CAF1M
- UniProt
- P26949, P26948, P26926
- Pockets
- 7 · best druggability 0.56
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F1 capsule-anchoring protein | protein | 131 | 17% helix, 32% strand | P26949 |
| B | F1 capsule antigen | protein | 135 | 2% helix, 50% strand | P26948 |
| M | Chaperone protein CAF1M | protein | 212 | 3% helix, 53% strand | P26926 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 312 | 0.56 | 0.76 | 49 | empty |
| 2 | 115 | 0.42 | 0.76 | 18 | empty |
| 3 | 116 | 0.41 | 0.76 | 23 | empty |
| 4 | 80 | 0.37 | 0.77 | 21 | empty |
| 5 | 106 | 0.36 | 0.74 | 17 | empty |
Interfaces
3 interfaces between chains.
- B–M · 1965 Ų buried · 42 hydrogen bonds · protein-protein
- A–M · 1134 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 90 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4B0M · Complex of the Caf1AN usher domain, Caf1M chaperone and Caf1 subunit from Yersinia pestis · the same entry in another collection · chain A against A, TM-score 1.00
- P26948 · AlphaFold monomer V2.0 prediction for F1 capsule antigen (P26948) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P26926 · AlphaFold monomer V2.0 prediction for chaperone protein CAF1M (P26926) · a predicted model of the same protein · chain M against A, TM-score 0.98
- P26949 · AlphaFold monomer V2.0 prediction for F1 capsule-anchoring protein (P26949) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26949
- Every structure of UniProt P26948
- Every structure of UniProt P26926
- Elsewhere: RCSB PDB 4B0M · PDBe 4B0M · UniProt P26949 · UniProt P26948 · UniProt P26926
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