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Inositol 1,3,4,5,6-pentakisphosphate 2-kinase apo form

Analyse Inositol 1,3,4,5,6-pentakisphosphate 2-kinase apo form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4AXC
Type: protein
Length: 394 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inositol-pentakisphosphate 2-kinase
EC: 2.7.1.158
UniProt: Q93YN9
Ligands: ZN, SO4
Pockets: 3 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158)	protein	394	44% helix, 18% strand	Q93YN9

Ligands and binding sites

ZN · Zinc ion · metal · chains A
SO4 · Sulfate ion · ion · 4 copies · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	684	0.73	0.80	61	SO4
2	245	0.68	0.84	35	SO4
3	50	0.30	0.77	12	SO4

Compared structures

4AXC · Inositol 1,3,4,5,6-pentakisphosphate 2-kinase apo form · the same entry in another collection · chain A against A, TM-score 1.00
Q93YN9 · AlphaFold monomer V2.0 prediction for inositol-pentakisphosphate 2-kinase (Q93YN9) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q93YN9
Elsewhere: RCSB PDB 4AXC · PDBe 4AXC · UniProt Q93YN9

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