Research workbench
Prolyl oligopeptidase from porcine brain, H680A mutant
Analyse Prolyl oligopeptidase from porcine brain, H680A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4AX4
- Type
- protein
- Length
- 700 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prolyl oligopeptidase
- EC
- 3.4.21.26
- UniProt
- P23687
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 23% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prolyl oligopeptidase (EC 3.4.21.26) | protein | 700 | 23% helix, 35% strand | P23687 |
Ligands and binding sites
- GOL · Glycerol · additive · 9 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.72 | 0.81 | 69 | empty |
| 2 | 321 | 0.66 | 0.81 | 33 | GOL |
| 3 | 90 | 0.42 | 0.79 | 19 | empty |
| 4 | 80 | 0.38 | 0.77 | 17 | GOL |
| 5 | 73 | 0.30 | 0.73 | 22 | GOL |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23687
- Elsewhere: RCSB PDB 4AX4 · PDBe 4AX4 · UniProt P23687
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