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Crystal structure of the DNA-binding domain of human ETV1.

Analyse Crystal structure of the DNA-binding domain of human ETV1. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4AVP
Type: protein
Length: 372 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ets translocation variant 1
UniProt: P50549
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Ets translocation variant 1	protein	93	49% helix, 15% strand	P50549

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 2 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	819	0.73	0.78	87	empty

Interfaces

5 interfaces between chains.

C–D · 854 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 843 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 372 Å² buried · 3 hydrogen bonds · protein-protein
B–D · 337 Å² buried · 1 hydrogen bond · protein-protein
B–C · 31 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4AVP · Crystal structure of the DNA-binding domain of human ETV1. · the same entry in another collection · chain D against D, TM-score 1.00
P50549 · AlphaFold monomer V2.0 prediction for ets translocation variant 1 (P50549) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50549
Elsewhere: RCSB PDB 4AVP · PDBe 4AVP · UniProt P50549

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