Research workbench
MITF:E-box complex
Analyse MITF:E-box complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ATK
- Type
- protein + DNA
- Length
- 152 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microphthalmia-associated transcription factor…
- UniProt
- Q08874
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Microphthalmia-associated transcription factor | protein | 60 | 78% helix, 0% strand | Q08874 |
| B | Microphthalmia-associated transcription factor | protein | 60 | 77% helix, 0% strand | Q08874 |
| C, D | 5'-D(*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*T)-3' | dna | 16 | — | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.66 | 0.96 | 14 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1125 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 688 Ų buried · 54 hydrogen bonds · nucleic-nucleic
- A–C · 472 Ų buried · 10 hydrogen bonds · protein-nucleic
- B–D · 472 Ų buried · 12 hydrogen bonds · protein-nucleic
- A–D · 306 Ų buried · 5 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08874
- Elsewhere: RCSB PDB 4ATK · PDBe 4ATK · UniProt Q08874
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