Research workbench
Crystal structure of the human RACK1 protein at a resolution of 2.45 ångström
Analyse Crystal structure of the human RACK1 protein at a resolution of 2.45 ångström in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4AOW
- Type
- protein
- Length
- 911 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein subunit beta-2-like 1
- UniProt
- P63244
- Pockets
- 7 · best druggability 0.85
Structure
x-ray diffraction · 3 distinct chains · 0% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein subunit beta-2-like 1 | protein | 305 | 0% helix, 55% strand | P63244 |
| B | Guanine nucleotide-binding protein subunit beta-2-like 1 | protein | 301 | 0% helix, 55% strand | P63244 |
| C | Guanine nucleotide-binding protein subunit beta-2-like 1 | protein | 305 | 0% helix, 55% strand | P63244 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1157 | 0.85 | 0.86 | 91 | GOL |
| 2 | 908 | 0.81 | 0.83 | 62 | empty |
| 3 | 1200 | 0.81 | 0.82 | 89 | GOL |
| 4 | 215 | 0.54 | 0.78 | 36 | empty |
| 5 | 210 | 0.48 | 0.74 | 28 | empty |
Interfaces
2 interfaces between chains.
- B–C · 610 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 307 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4AOW · Crystal structure of the human Rack1 protein at a resolution of 2.45 angstrom · the same entry in another collection · chain A against A, TM-score 1.00
- P63244 · AlphaFold monomer V2.0 prediction for receptor of activated protein C kinase 1 (P63244) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63244
- Elsewhere: RCSB PDB 4AOW · PDBe 4AOW · UniProt P63244
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