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Crystal structure of human sorting nexin 33 (SNX33)
Analyse Crystal structure of human sorting nexin 33 (SNX33) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4AKV
- Type
- protein
- Length
- 694 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sorting nexin-33
- UniProt
- Q8WV41
- Ligands
- SO4
- Pockets
- 8 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sorting nexin-33 | protein | 345 | 70% helix, 5% strand | Q8WV41 |
| B | Sorting nexin-33 | protein | 349 | 68% helix, 5% strand | Q8WV41 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.42 | 0.76 | 20 | empty |
| 2 | 64 | 0.40 | 0.80 | 16 | empty |
| 3 | 97 | 0.39 | 0.76 | 21 | empty |
| 4 | 83 | 0.38 | 0.77 | 16 | empty |
| 5 | 63 | 0.33 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 3003 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WV41
- Elsewhere: RCSB PDB 4AKV · PDBe 4AKV · UniProt Q8WV41
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