Research workbench

Mtssl spin labeled D67C mutant of mscs in the open form

Analyse Mtssl spin labeled D67C mutant of mscs in the open form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4AGE
Type: protein
Length: 1,792 residues
Chains: 7
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Small-conductance mechanosensitive channel
UniProt: P0C0S2
Pockets: 20 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Small-conductance mechanosensitive channel	protein	256	48% helix, 23% strand	P0C0S2

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1099	0.79	0.80	114	empty
2	671	0.75	0.80	76	empty
3	839	0.74	0.78	66	empty
4	487	0.74	0.82	71	empty
5	226	0.71	0.86	28	empty

Interfaces

14 interfaces between chains.

A–G · 2437 Å² buried · 26 hydrogen bonds · protein-protein
F–G · 2436 Å² buried · 23 hydrogen bonds · protein-protein
A–B · 2431 Å² buried · 24 hydrogen bonds · protein-protein
E–F · 2431 Å² buried · 22 hydrogen bonds · protein-protein
B–C · 2418 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

4AGE · MTSSL spin labeled D67C mutant of MscS in the open form · the same entry in another collection · chain G against G, TM-score 1.00
P0C0S2 · AlphaFold monomer V2.0 prediction for small-conductance mechanosensitive channel (P0C0S2) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0C0S2
Elsewhere: RCSB PDB 4AGE · PDBe 4AGE · UniProt P0C0S2

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