Research workbench
Crystal structure of the anti-aahi FAB9C2 antibody
Analyse Crystal structure of the anti-aahi FAB9C2 antibody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4AEH
- Type
- protein
- Length
- 430 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab antibody, heavy chain; Fab antibody, light chain
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Fab antibody, heavy chain | protein | 219 | 8% helix, 53% strand | — |
| L | Fab antibody, light chain | protein | 211 | 6% helix, 54% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 457 | 0.61 | 0.75 | 60 | empty |
| 2 | 174 | 0.44 | 0.74 | 24 | empty |
| 3 | 55 | 0.35 | 0.78 | 15 | empty |
| 4 | 53 | 0.26 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- H–L · 1798 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4AEH · Crystal structure of the anti-AaHI Fab9C2 antibody · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4AEH · PDBe 4AEH
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