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Crosstalk between CU(I) and ZN(II) homeostasis

Analyse Crosstalk between CU(I) and ZN(II) homeostasis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4A47
Type: protein
Length: 252 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SSR2857 protein
UniProt: P73213
Ligands: ZN
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	SSR2857 protein	protein	63	35% helix, 24% strand	P73213

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	529	0.72	0.81	58	empty

Interfaces

5 interfaces between chains.

A–B · 351 Å² buried · 7 hydrogen bonds · protein-protein
B–D · 284 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 275 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 272 Å² buried · 6 hydrogen bonds · protein-protein
C–D · 143 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4A47 · Crosstalk between Cu(I) and Zn(II) homeostasis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P73213
Elsewhere: RCSB PDB 4A47 · PDBe 4A47 · UniProt P73213

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