Research workbench
Structure of duck rig-I tandem cards and helicase domain
Analyse Structure of duck rig-I tandem cards and helicase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4A2Q
- Type
- protein
- Length
- 2,690 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Retinoic acid inducible protein I
- UniProt
- D3TI84
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 4 distinct chains · 61% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Retinoic acid inducible protein I | protein | 674 | 62% helix, 8% strand | D3TI84 |
| B | Retinoic acid inducible protein I | protein | 675 | 62% helix, 8% strand | D3TI84 |
| D | Retinoic acid inducible protein I | protein | 671 | 60% helix, 8% strand | D3TI84 |
| E | Retinoic acid inducible protein I | protein | 670 | 60% helix, 8% strand | D3TI84 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1196 | 0.81 | 0.82 | 100 | empty |
| 2 | 1111 | 0.80 | 0.81 | 94 | empty |
| 3 | 997 | 0.78 | 0.80 | 86 | empty |
| 4 | 738 | 0.71 | 0.77 | 64 | empty |
| 5 | 687 | 0.70 | 0.77 | 57 | empty |
Interfaces
6 interfaces between chains.
- D–E · 1197 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1036 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 406 Ų buried · 1 hydrogen bond · protein-protein
- A–E · 385 Ų buried · 1 hydrogen bond · protein-protein
- B–E · 355 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4A2Q · Structure of duck RIG-I tandem CARDs and helicase domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D3TI84
- Elsewhere: RCSB PDB 4A2Q · PDBe 4A2Q · UniProt D3TI84
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