Research workbench
Structural and functional analyses of the BRO1 domain protein brox
Analyse Structural and functional analyses of the BRO1 domain protein brox in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZXP
- Type
- protein
- Length
- 1,162 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BRO1 domain-containing protein brox
- UniProt
- Q5VW32
- Pockets
- 13 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 58% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BRO1 domain-containing protein brox | protein | 394 | 57% helix, 3% strand | Q5VW32 |
| B | BRO1 domain-containing protein brox | protein | 384 | 58% helix, 3% strand | Q5VW32 |
| C | BRO1 domain-containing protein brox | protein | 384 | 58% helix, 2% strand | Q5VW32 |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 158 | 0.59 | 0.83 | 26 | empty |
| 2 | 157 | 0.56 | 0.81 | 26 | empty |
| 3 | 240 | 0.52 | 0.76 | 27 | empty |
| 4 | 135 | 0.50 | 0.79 | 25 | empty |
| 5 | 165 | 0.49 | 0.77 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–C · 560 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 558 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 529 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3ZXP · Structural and Functional Analyses of the Bro1 Domain Protein BROX · the same entry in another collection · chain A against A, TM-score 1.00
- Q5VW32 · AlphaFold monomer V2.0 prediction for BRO1 domain-containing protein brox (Q5VW32) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5VW32
- Elsewhere: RCSB PDB 3ZXP · PDBe 3ZXP · UniProt Q5VW32
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