Research workbench
Crystal structure of the pore-forming toxin frac from actinia fragacea (form 3)
Analyse Crystal structure of the pore-forming toxin frac from actinia fragacea (form 3) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZWJ
- Type
- protein
- Length
- 1,593 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fragaceatoxin C
- UniProt
- B9W5G6
- Pockets
- 20 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 12% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I | Fragaceatoxin C | protein | 177 | 12% helix, 48% strand | B9W5G6 |
Pockets
20 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 162 | 0.50 | 0.78 | 24 | empty |
| 2 | 268 | 0.50 | 0.74 | 40 | empty |
| 3 | 254 | 0.49 | 0.74 | 42 | empty |
| 4 | 260 | 0.49 | 0.74 | 45 | empty |
| 5 | 124 | 0.47 | 0.78 | 19 | empty |
Interfaces
14 interfaces between chains.
- D–E · 685 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 685 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 661 Ų buried · 7 hydrogen bonds · protein-protein
- H–I · 657 Ų buried · 7 hydrogen bonds · protein-protein
- G–H · 654 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3ZWJ · CRYSTAL STRUCTURE OF THE PORE-FORMING TOXIN FRAC FROM ACTINIA FRAGACEA (Form 3) · the same entry in another collection · chain I against I, TM-score 1.00
- B9W5G6 · AlphaFold monomer V2.0 prediction for delta-actitoxin-AFR1A (B9W5G6) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B9W5G6
- Elsewhere: RCSB PDB 3ZWJ · PDBe 3ZWJ · UniProt B9W5G6
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