Research workbench
Crystal structure of the pore-forming toxin frac from actinia fragacea (form 2)
Analyse Crystal structure of the pore-forming toxin frac from actinia fragacea (form 2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZWG
- Type
- protein
- Length
- 2,670 residues
- Chains
- 15
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fragaceatoxin C
- UniProt
- B9W5G6
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 12% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | Fragaceatoxin C | protein | 178 | 12% helix, 47% strand | B9W5G6 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 985 | 0.73 | 0.76 | 103 | empty |
| 2 | 290 | 0.61 | 0.79 | 46 | empty |
| 3 | 350 | 0.59 | 0.77 | 39 | empty |
| 4 | 382 | 0.56 | 0.75 | 48 | empty |
| 5 | 373 | 0.55 | 0.74 | 52 | empty |
Interfaces
26 interfaces between chains.
- A–B · 752 Ų buried · 12 hydrogen bonds · protein-protein
- N–O · 748 Ų buried · 13 hydrogen bonds · protein-protein
- E–F · 740 Ų buried · 10 hydrogen bonds · protein-protein
- M–N · 728 Ų buried · 13 hydrogen bonds · protein-protein
- D–E · 721 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3ZWG · Crystal structure of the pore-forming toxin FraC from Actinia fragacea (form 2) · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B9W5G6
- Elsewhere: RCSB PDB 3ZWG · PDBe 3ZWG · UniProt B9W5G6
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