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The structure of OST1 (D160A) kinase

Analyse The structure of OST1 (D160A) kinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3ZUT
Type: protein
Length: 563 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase SRK2E
EC: 2.7.11.1
UniProt: Q940H6
Pockets: 6 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase SRK2E (EC 2.7.11.1)	protein	281	38% helix, 15% strand	Q940H6
B	SERINE/THREONINE-protein kinase SRK2E (EC 2.7.11.1)	protein	282	39% helix, 15% strand	Q940H6

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1169	0.75	0.78	127	empty
2	97	0.43	0.78	15	empty
3	69	0.37	0.78	17	empty
4	77	0.31	0.74	19	empty
5	58	0.27	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 825 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

3ZUT · The structure of OST1 (D160A) kinase · the same entry in another collection · chain A against A, TM-score 1.00
Q940H6 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase SRK2E (Q940H6) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q940H6
Elsewhere: RCSB PDB 3ZUT · PDBe 3ZUT · UniProt Q940H6

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