Research workbench
Structure of SENP2-LOOP1 in complex with presumo-2
Analyse Structure of SENP2-LOOP1 in complex with presumo-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZO5
- Type
- protein
- Length
- 311 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sentrin-specific protease 2; Small ubiquitin-related modifier 2
- EC
- 3.4.22.68
- UniProt
- Q9HC62, P61956
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sentrin-specific protease 2 (EC 3.4.22.68) | protein | 230 | 46% helix, 16% strand | Q9HC62 |
| B | Small ubiquitin-related modifier 2 | protein | 81 | 19% helix, 35% strand | P61956 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 626 | 0.73 | 0.80 | 63 | empty |
| 2 | 80 | 0.36 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1238 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 3ZO5 · Structure of SENP2-Loop1 in complex with preSUMO-2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HC62 · AlphaFold monomer V2.0 prediction for sentrin-specific protease 2 (Q9HC62) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P61956 · AlphaFold monomer V2.0 prediction for small ubiquitin-related modifier 2 (P61956) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HC62
- Every structure of UniProt P61956
- Elsewhere: RCSB PDB 3ZO5 · PDBe 3ZO5 · UniProt Q9HC62 · UniProt P61956
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