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Structure of group a streptococcal enolase K362A mutant

Analyse Structure of group a streptococcal enolase K362A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3ZLG
Type: protein
Length: 1,732 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enolase
EC: 4.2.1.11
UniProt: Q5XD01
Ligands: PO4
Pockets: 18 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Enolase (EC 4.2.1.11)	protein	433	42% helix, 18% strand	Q5XD01

Ligands and binding sites

PO4 · Phosphate ion · ion · 8 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	294	0.85	0.96	35	empty
2	1009	0.78	0.80	50	empty
3	329	0.70	0.83	38	empty
4	292	0.63	0.80	37	empty
5	300	0.62	0.79	36	empty

Interfaces

3 interfaces between chains.

C–D · 1827 Å² buried · 40 hydrogen bonds · protein-protein
A–B · 1234 Å² buried · 16 hydrogen bonds · protein-protein
B–D · 241 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

3ZLG · Structure of group A Streptococcal enolase K362A mutant · the same entry in another collection · chain D against D, TM-score 1.00
Q5XD01 · AlphaFold monomer V2.0 prediction for enolase (Q5XD01) · a predicted model of the same protein · chain C against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5XD01
Elsewhere: RCSB PDB 3ZLG · PDBe 3ZLG · UniProt Q5XD01

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