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Crystal structure of toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2
Analyse Crystal structure of toxoplasma gondii sporozoite AMA1 in complex with a 36 aa… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZLD
- Type
- protein
- Length
- 393 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apical membrane antigen 1; Rhoptry neck protein 2
- UniProt
- B6K9M7, B6KLP1
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apical membrane antigen 1 | protein | 363 | 15% helix, 29% strand | B6K9M7 |
| B | Rhoptry neck protein 2 | protein | 30 | 17% helix, 30% strand | B6KLP1 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 180 | 0.60 | 0.82 | 30 | empty |
| 2 | 58 | 0.34 | 0.77 | 14 | empty |
| 3 | 65 | 0.31 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1672 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 3ZLD · Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of… · the same entry in another collection · chain A against A, TM-score 1.00
- B6K9M7 · AlphaFold monomer V2.0 prediction for apical membrane antigen 1-like protein (B6K9M7) · a predicted model of the same protein · chain A against A, TM-score 0.90
- B6KLP1 · AlphaFold monomer V2.0 prediction for rhoptry neck protein 2-like protein 2 (B6KLP1) · a predicted model of the same protein · chain B against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B6K9M7
- Every structure of UniProt B6KLP1
- Elsewhere: RCSB PDB 3ZLD · PDBe 3ZLD · UniProt B6K9M7 · UniProt B6KLP1
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