Research workbench
Crystal structure of mouse claudin-19 in complex with C-terminal fragment of clostridium perfringens enterotoxin
Analyse Crystal structure of mouse claudin-19 in complex with C-terminal fragment of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3X29
- Type
- protein
- Length
- 563 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Claudin-19; Heat-labile enterotoxin B chain
- UniProt
- Q9ET38, P01558
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 48% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Claudin-19 | protein | 166 | 64% helix, 14% strand | Q9ET38 |
| B, D | Heat-labile enterotoxin B chain | protein | 117 | 4% helix, 53% strand | P01558 |
| C | Claudin-19 | protein | 163 | 64% helix, 13% strand | Q9ET38 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 560 | 0.74 | 0.81 | 46 | empty |
| 2 | 500 | 0.72 | 0.81 | 42 | empty |
| 3 | 357 | 0.60 | 0.76 | 33 | empty |
| 4 | 62 | 0.39 | 0.80 | 15 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1109 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 1084 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 790 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 164 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 164 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3X29 · CRYSTAL STRUCTURE of MOUSE CLAUDIN-19 IN COMPLEX with C-TERMINAL FRAGMENT OF CLOSTRIDIUM… · the same entry in another collection · chain D against D, TM-score 1.00
- P01558 · AlphaFold monomer V2.0 prediction for heat-labile enterotoxin B chain (P01558) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q9ET38 · AlphaFold monomer V2.0 prediction for claudin-19 (Q9ET38) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ET38
- Every structure of UniProt P01558
- Elsewhere: RCSB PDB 3X29 · PDBe 3X29 · UniProt Q9ET38 · UniProt P01558
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.