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Crystal structure of F97A mutant, a new nuclear transport receptor of HSP70

Analyse Crystal structure of F97A mutant, a new nuclear transport receptor of HSP70 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3WW0
Type: protein
Length: 352 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein hikeshi
UniProt: Q53FT3
Pockets: 3 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein hikeshi	protein	177	26% helix, 33% strand	Q53FT3
B	Protein hikeshi	protein	175	27% helix, 35% strand	Q53FT3

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	256	0.55	0.77	46	empty
2	61	0.37	0.79	15	empty
3	74	0.31	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 2806 Å² buried · 38 hydrogen bonds · protein-protein

Compared structures

3WW0 · Crystal structure of F97A mutant, a new nuclear transport receptor of Hsp70 · the same entry in another collection · chain A against A, TM-score 1.00
Q53FT3 · AlphaFold monomer V2.0 prediction for protein hikeshi (Q53FT3) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53FT3
Elsewhere: RCSB PDB 3WW0 · PDBe 3WW0 · UniProt Q53FT3

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