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Crystal structure of hikeshi, a new nuclear transport receptor of HSP70

Analyse Crystal structure of hikeshi, a new nuclear transport receptor of HSP70 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3WVZ
Type: protein
Length: 370 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein hikeshi
UniProt: Q53FT3
Pockets: 3 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein hikeshi	protein	192	22% helix, 30% strand	Q53FT3
B	Protein hikeshi	protein	178	26% helix, 33% strand	Q53FT3

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	190	0.43	0.73	25	empty
2	65	0.35	0.77	16	empty
3	56	0.35	0.78	16	empty

Interfaces

1 interface between chains.

A–B · 2656 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

3WVZ · Crystal structure of Hikeshi, a new nuclear transport receptor of Hsp70 · the same entry in another collection · chain A against A, TM-score 1.00
Q53FT3 · AlphaFold monomer V2.0 prediction for protein hikeshi (Q53FT3) · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53FT3
Elsewhere: RCSB PDB 3WVZ · PDBe 3WVZ · UniProt Q53FT3

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