Research workbench
Reduced-form structure of E.COLI lon proteolytic domain
Analyse Reduced-form structure of E.COLI lon proteolytic domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3WU3
- Type
- protein
- Length
- 1,102 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lon protease
- EC
- 3.4.21.53
- UniProt
- C9QQ79
- Ligands
- SO4
- Pockets
- 16 · best druggability 0.58
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lon protease (EC 3.4.21.53) | protein | 190 | 38% helix, 30% strand | C9QQ79 |
| B, C, D | Lon protease (EC 3.4.21.53) | protein | 181 | 35% helix, 28% strand | C9QQ79 |
| E | Lon protease (EC 3.4.21.53) | protein | 190 | 34% helix, 27% strand | C9QQ79 |
| F | Lon protease (EC 3.4.21.53) | protein | 179 | 37% helix, 28% strand | C9QQ79 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 5 copies · chains B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 210 | 0.58 | 0.80 | 29 | empty |
| 2 | 135 | 0.58 | 0.84 | 25 | empty |
| 3 | 126 | 0.53 | 0.81 | 22 | empty |
| 4 | 126 | 0.53 | 0.81 | 26 | empty |
| 5 | 104 | 0.52 | 0.83 | 23 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1283 Ų buried · 25 hydrogen bonds · protein-protein
- A–F · 795 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 784 Ų buried · 13 hydrogen bonds · protein-protein
- E–F · 763 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 760 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3WU3 · Reduced-form structure of E.coli Lon Proteolytic domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C9QQ79
- Elsewhere: RCSB PDB 3WU3 · PDBe 3WU3 · UniProt C9QQ79
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