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Wild type beta-lactamase derived from chromohalobacter SP.560

Analyse Wild type beta-lactamase derived from chromohalobacter SP.560 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3WRT
Type: protein
Length: 1,069 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactamase
EC: 3.5.2.6
UniProt: Q76LX5
Pockets: 7 · best druggability 0.69

Structure

x-ray diffraction · 3 distinct chains · 39% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-lactamase (EC 3.5.2.6)	protein	357	40% helix, 19% strand	Q76LX5
B	Beta-lactamase (EC 3.5.2.6)	protein	356	39% helix, 19% strand	Q76LX5
C	Beta-lactamase (EC 3.5.2.6)	protein	356	39% helix, 19% strand	Q76LX5

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	614	0.69	0.78	57	empty
2	712	0.69	0.76	70	empty
3	303	0.56	0.76	37	empty
4	289	0.56	0.76	41	empty
5	300	0.55	0.76	40	empty

Interfaces

2 interfaces between chains.

A–C · 342 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 311 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

3WRT · Wild type beta-lactamase DERIVED FROM CHROMOHALOBACTER SP.560 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q76LX5
Elsewhere: RCSB PDB 3WRT · PDBe 3WRT · UniProt Q76LX5

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