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Crystal structure of CLASP2 tog domain (TOG3)

Analyse Crystal structure of CLASP2 tog domain (TOG3) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3WOZ
Type: protein
Length: 905 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Clip-associating protein 2
UniProt: Q8BRT1
Pockets: 7 · best druggability 0.57

Structure

x-ray diffraction · 3 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Clip-associating protein 2	protein	225	75% helix, 0% strand	Q8BRT1
B, C	Clip-associating protein 2	protein	229	76% helix, 0% strand	Q8BRT1
D	Clip-associating protein 2	protein	222	74% helix, 0% strand	Q8BRT1

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	181	0.57	0.81	30	empty
2	251	0.47	0.73	32	empty
3	108	0.45	0.79	20	empty
4	174	0.41	0.73	21	empty
5	110	0.39	0.75	25	empty

Interfaces

5 interfaces between chains.

A–B · 489 Å² buried · 6 hydrogen bonds · protein-protein
C–D · 467 Å² buried · 10 hydrogen bonds · protein-protein
B–D · 148 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 91 Å² buried · 0 hydrogen bonds · protein-protein
A–D · 64 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 25 modified (engineered).

Compared structures

3WOZ · Crystal structure of CLASP2 TOG domain (TOG3) · the same entry in another collection · chain D against D, TM-score 1.00
Q8BRT1 · AlphaFold monomer V2.0 prediction for clip-associating protein 2 (Q8BRT1) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8BRT1
Elsewhere: RCSB PDB 3WOZ · PDBe 3WOZ · UniProt Q8BRT1

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