Research workbench
HLA-A24 in complex with HIV-1 NEF126-10(8I10F)
Analyse HLA-A24 in complex with HIV-1 NEF126-10(8I10F) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3WL9
- Type
- protein
- Length
- 384 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, a-24 alpha chain; Beta-2-microglobulin; Protein…
- UniProt
- P05534, P61769, Q9Q5D4
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, a-24 alpha chain | protein | 274 | 28% helix, 40% strand | P05534 |
| B | Beta-2-microglobulin | protein | 100 | 0% helix, 49% strand | P61769 |
| C | Protein nef | protein | 10 | 0% helix, 0% strand | Q9Q5D4 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 620 | 0.68 | 0.77 | 59 | empty |
| 2 | 73 | 0.67 | 0.93 | 21 | empty |
| 3 | 163 | 0.50 | 0.78 | 26 | empty |
| 4 | 77 | 0.40 | 0.78 | 21 | empty |
| 5 | 67 | 0.35 | 0.77 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1417 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 904 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05534
- Every structure of UniProt P61769
- Every structure of UniProt Q9Q5D4
- Elsewhere: RCSB PDB 3WL9 · PDBe 3WL9 · UniProt P05534 · UniProt P61769 · UniProt Q9Q5D4
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