Research workbench
Crystal structure of the eukaryotic initiation factor
Analyse Crystal structure of the eukaryotic initiation factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3WJ9
- Type
- protein
- Length
- 798 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 2A
- UniProt
- O74965
- Pockets
- 10 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 2A | protein | 396 | 2% helix, 48% strand | O74965 |
| B | Eukaryotic translation initiation factor 2A | protein | 402 | 1% helix, 43% strand | O74965 |
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 454 | 0.64 | 0.77 | 59 | empty |
| 2 | 148 | 0.53 | 0.80 | 19 | empty |
| 3 | 192 | 0.49 | 0.76 | 35 | empty |
| 4 | 248 | 0.45 | 0.72 | 33 | empty |
| 5 | 205 | 0.44 | 0.73 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 640 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 3WJ9 · Crystal structure of the eukaryotic initiation factor · the same entry in another collection · chain A against A, TM-score 1.00
- O74965 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2A (O74965) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O74965
- Elsewhere: RCSB PDB 3WJ9 · PDBe 3WJ9 · UniProt O74965
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