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Crystal structure of the eucaryotic mono-ADP-ribosyltransferase ART2.2; crystal form C (P3121)

Analyse Crystal structure of the eucaryotic mono-ADP-ribosyltransferase ART2.2; crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1GY0
Type: protein
Length: 223 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-cell ecto-ADP-ribosyltransferase 2
EC: 2.4.2.31
UniProt: P20974
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	T-cell ecto-ADP-ribosyltransferase 2 (EC 2.4.2.31)	protein	223	35% helix, 21% strand	P20974

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	375	0.64	0.79	43	empty
2	86	0.38	0.77	17	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1GY0 · crystal structure of the eucaryotic mono-ADP-ribosyltransferase ART2.2; CRYSTAL FORM C… · the same entry in another collection · chain A against A, TM-score 1.00
P20974 · AlphaFold monomer V2.0 prediction for T-cell ecto-ADP- ribosyltransferase 2 (P20974) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20974
Elsewhere: RCSB PDB 1GY0 · PDBe 1GY0 · UniProt P20974

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