Research workbench
Crystal structure of KEAP1 in complex with phosphorylated P62
Analyse Crystal structure of KEAP1 in complex with phosphorylated P62 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3WDZ
- Type
- protein
- Length
- 296 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kelch-like ech-associated protein 1; Peptide from sequestosome-1
- UniProt
- Q9Z2X8, Q64337
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kelch-like ech-associated protein 1 | protein | 285 | 1% helix, 52% strand | Q9Z2X8 |
| B | Peptide from sequestosome-1 | protein | 11 | 0% helix, 18% strand | Q64337 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.74 | 0.82 | 54 | empty |
Interfaces
1 interface between chains.
- A–B · 530 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 3WDZ · Crystal Structure of Keap1 in Complex with phosphorylated p62 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Z2X8 · AlphaFold monomer V2.0 prediction for kelch-like ech-associated protein 1 (Q9Z2X8) · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q64337 · AlphaFold monomer V2.0 prediction for sequestosome-1 (Q64337) · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z2X8
- Every structure of UniProt Q64337
- Elsewhere: RCSB PDB 3WDZ · PDBe 3WDZ · UniProt Q9Z2X8 · UniProt Q64337
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