Research workbench
Crystal structure of KAP121P bound to PHO4P
Analyse Crystal structure of KAP121P bound to PHO4P in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3W3X
- Type
- protein
- Length
- 1,031 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit beta-3; Phosphate system positive regulatory protein PHO4
- UniProt
- P32337, P07270
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit beta-3 | protein | 1021 | 77% helix, 1% strand | P32337 |
| B | Phosphate system positive regulatory protein PHO4 | protein | 10 | 0% helix, 0% strand | P07270 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 257 | 0.64 | 0.82 | 46 | empty |
| 2 | 233 | 0.50 | 0.75 | 39 | empty |
| 3 | 78 | 0.34 | 0.75 | 20 | empty |
| 4 | 87 | 0.33 | 0.73 | 14 | empty |
| 5 | 55 | 0.29 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 702 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3W3X · Crystal structure of Kap121p bound to Pho4p · the same entry in another collection · chain A against A, TM-score 1.00
- P32337 · AlphaFold monomer V2.0 prediction for importin subunit beta-3 (P32337) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P07270 · AlphaFold monomer V2.0 prediction for phosphate system positive regulatory protein PHO4… · a predicted model of the same protein · chain B against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32337
- Every structure of UniProt P07270
- Elsewhere: RCSB PDB 3W3X · PDBe 3W3X · UniProt P32337 · UniProt P07270
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