Research workbench
Crystal structure of KAP121P bound to STE12P
Analyse Crystal structure of KAP121P bound to STE12P in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3W3W
- Type
- protein
- Length
- 1,040 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit beta-3; Protein STE12
- UniProt
- P32337, P13574
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit beta-3 | protein | 1028 | 76% helix, 1% strand | P32337 |
| B | Protein STE12 | protein | 12 | 0% helix, 0% strand | P13574 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 196 | 0.56 | 0.80 | 37 | empty |
| 2 | 233 | 0.47 | 0.74 | 34 | empty |
| 3 | 77 | 0.41 | 0.79 | 13 | empty |
| 4 | 68 | 0.30 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 728 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3W3W · Crystal structure of Kap121p bound to Ste12p · the same entry in another collection · chain A against A, TM-score 1.00
- P32337 · AlphaFold monomer V2.0 prediction for importin subunit beta-3 (P32337) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P13574 · AlphaFold monomer V2.0 prediction for protein STE12 (P13574) · a predicted model of the same protein · chain B against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32337
- Every structure of UniProt P13574
- Elsewhere: RCSB PDB 3W3W · PDBe 3W3W · UniProt P32337 · UniProt P13574
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