Research workbench
Crystal structure of peroxiredoxin 4 from M. musculus
Analyse Crystal structure of peroxiredoxin 4 from M. musculus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3VWU
- Type
- protein
- Length
- 1,695 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxiredoxin-4
- EC
- 1.11.1.15
- UniProt
- O08807
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 6 distinct chains · 28% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, H | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 172 | 27% helix, 27% strand | O08807 |
| B, G, I | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 167 | 30% helix, 28% strand | O08807 |
| C | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 173 | 27% helix, 26% strand | O08807 |
| D, F | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 170 | 28% helix, 26% strand | O08807 |
| E | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 171 | 27% helix, 26% strand | O08807 |
| J | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 166 | 30% helix, 27% strand | O08807 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 88 | 0.77 | 0.98 | 22 | empty |
| 2 | 58 | 0.72 | 0.99 | 20 | empty |
| 3 | 55 | 0.72 | 0.99 | 23 | empty |
| 4 | 56 | 0.71 | 0.98 | 22 | empty |
| 5 | 52 | 0.70 | 0.98 | 20 | empty |
Interfaces
13 interfaces between chains.
- C–D · 1516 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 1307 Ų buried · 20 hydrogen bonds · protein-protein
- G–H · 1291 Ų buried · 23 hydrogen bonds · protein-protein
- E–F · 1121 Ų buried · 18 hydrogen bonds · protein-protein
- I–J · 866 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O08807
- Elsewhere: RCSB PDB 3VWU · PDBe 3VWU · UniProt O08807
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