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Crystal strucuture of the ethidium-bound form of ramr (transcriptional regurator of tetr family) from salmonella typhimurium
Analyse Crystal strucuture of the ethidium-bound form of ramr (transcriptional… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3VVY
- Type
- protein
- Length
- 737 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative regulatory protein
- UniProt
- D0ZP76
- Ligands
- ET
- Pockets
- 6 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 79% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Putative regulatory protein | protein | 184 | 80% helix, 1% strand | D0ZP76 |
| C | Putative regulatory protein | protein | 186 | 80% helix, 1% strand | D0ZP76 |
| D | Putative regulatory protein | protein | 183 | 79% helix, 1% strand | D0ZP76 |
Ligands and binding sites
- ET · Ethidium · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 495 | 0.82 | 0.89 | 52 | ET |
| 2 | 429 | 0.82 | 0.89 | 52 | ET |
| 3 | 1169 | 0.81 | 0.82 | 91 | ET |
| 4 | 945 | 0.80 | 0.82 | 84 | ET |
| 5 | 447 | 0.61 | 0.76 | 37 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1296 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 1291 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 349 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3VVY · Crystal Strucuture of The Ethidium-Bound Form of RamR (Transcriptional Regurator of TetR… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D0ZP76
- Elsewhere: RCSB PDB 3VVY · PDBe 3VVY · UniProt D0ZP76
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