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Crystal structure of the merozoite surface protein MSPDBL2 from P. falciparum bound to zinc

Analyse Crystal structure of the merozoite surface protein MSPDBL2 from P. falciparum… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3VUV
Type: protein
Length: 276 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Erythrocyte membrane protein, putative
UniProt: Q8IJ45
Ligands: ZN
Pockets: 3 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Erythrocyte membrane protein, putative	protein	276	64% helix, 1% strand	Q8IJ45

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.44	0.80	14	empty
2	88	0.36	0.75	19	empty
3	68	0.31	0.75	16	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

3VUV · Crystal structure of the merozoite surface protein MSPDBL2 from P. falciparum bound to… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IJ45
Elsewhere: RCSB PDB 3VUV · PDBe 3VUV · UniProt Q8IJ45

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