Research workbench
Crystal structure of the chicken cenp-T histone FOLD/CENP-W/CENP- S/CENP-X heterotetrameric complex, crystal form II
Analyse Crystal structure of the chicken cenp-T histone FOLD/CENP-W/CENP- S/CENP-X… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3VH6
- Type
- protein
- Length
- 343 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cenp-S; Cenp-X; Cenp-T; Cenp-W
- UniProt
- F1NPG5
- Pockets
- 1 · best druggability 0.55
Structure
x-ray diffraction · 4 distinct chains · 73% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cenp-S | protein | 98 | 83% helix, 4% strand | — |
| D | Cenp-X | protein | 75 | 71% helix, 5% strand | — |
| T | Cenp-T | protein | 97 | 66% helix, 3% strand | F1NPG5 |
| W | Cenp-W | protein | 73 | 70% helix, 4% strand | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 323 | 0.55 | 0.75 | 30 | empty |
Interfaces
6 interfaces between chains.
- A–D · 2583 Ų buried · 26 hydrogen bonds · protein-protein
- T–W · 2526 Ų buried · 19 hydrogen bonds · protein-protein
- A–T · 604 Ų buried · 11 hydrogen bonds · protein-protein
- A–W · 221 Ų buried · 3 hydrogen bonds · protein-protein
- D–W · 119 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3VH6 · Crystal structure of the chicken CENP-T histone fold/CENP-W/CENP-S/CENP-X… · the same entry in another collection · chain A against A, TM-score 1.00
- F1NPG5 · AlphaFold monomer V2.0 prediction for centromere protein T (F1NPG5) · a predicted model of the same protein · chain T against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F1NPG5
- Elsewhere: RCSB PDB 3VH6 · PDBe 3VH6 · UniProt F1NPG5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.