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Crystal structure of -35 promoter binding domain of sigd of mycobacterium tuberculosis

Analyse Crystal structure of -35 promoter binding domain of sigd of mycobacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3VFZ
Type: protein
Length: 125 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable RNA polymerase sigma-D factor
UniProt: P66811
Pockets: 1 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 82% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable RNA polymerase sigma-D factor	protein	62	81% helix, 0% strand	P66811
B	Probable RNA polymerase sigma-D factor	protein	63	83% helix, 0% strand	P66811

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	137	0.68	0.88	19	empty

Interfaces

1 interface between chains.

A–B · 938 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

3VFZ · Crystal structure of -35 promoter binding domain of SigD of Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P66811
Elsewhere: RCSB PDB 3VFZ · PDBe 3VFZ · UniProt P66811

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