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Crystal structure of the C-terminal cytoplasmic domain of non- structural protein 4 from mouse hepatitis virus A59

Analyse Crystal structure of the C-terminal cytoplasmic domain of non- structural… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3VC8
Type: protein
Length: 166 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase
UniProt: Q9J3E9
Pockets: 2 · best druggability 0.37

Structure

x-ray diffraction · 2 distinct chains · 60% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase	protein	81	62% helix, 7% strand	Q9J3E9
B	RNA-directed RNA polymerase	protein	85	59% helix, 7% strand	Q9J3E9

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	108	0.37	0.74	19	empty
2	69	0.31	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 212 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3VC8 · Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9J3E9
Elsewhere: RCSB PDB 3VC8 · PDBe 3VC8 · UniProt Q9J3E9

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