Research workbench

Crystal structure of the extracellular domain of the putative hybrid two component system BT4673 from B. thetaiotaomicron

Analyse Crystal structure of the extracellular domain of the putative hybrid two… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3VA6
Type: protein
Length: 1,490 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Two-component system sensor histidine kinase
UniProt: Q89YQ8
Pockets: 16 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Two-component system sensor histidine kinase	protein	747	3% helix, 47% strand	Q89YQ8
B	Two-component system sensor histidine kinase	protein	743	2% helix, 48% strand	Q89YQ8

Pockets

16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1064	0.81	0.82	89	empty
2	1087	0.80	0.82	86	empty
3	1127	0.73	0.77	95	empty
4	919	0.73	0.77	66	empty
5	751	0.72	0.78	47	empty

Interfaces

1 interface between chains.

A–B · 2232 Å² buried · 36 hydrogen bonds · protein-protein

Compared structures

3VA6 · Crystal Structure of the extracellular domain of the putative hybrid two component system… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q89YQ8
Elsewhere: RCSB PDB 3VA6 · PDBe 3VA6 · UniProt Q89YQ8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.