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Crystal structure of the dengue virus serotype 2 envelope protein domain III in complex with the variable domains of mab 4E11
Analyse Crystal structure of the dengue virus serotype 2 envelope protein domain III in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UZV
- Type
- protein
- Length
- 326 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Envelope protein; Anti-dengue mab 4E11
- UniProt
- P07564
- Pockets
- 3 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Envelope protein | protein | 97 | 0% helix, 45% strand | P07564 |
| B | Anti-dengue mab 4E11 | protein | 229 | 5% helix, 50% strand | — |
Ligands and binding sites
- EOH · Ethanol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 95 | 0.35 | 0.74 | 19 | empty |
| 2 | 83 | 0.34 | 0.74 | 21 | empty |
| 3 | 74 | 0.32 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 976 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3UZV · Crystal structure of the dengue virus serotype 2 envelope protein domain III in complex… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07564
- Elsewhere: RCSB PDB 3UZV · PDBe 3UZV · UniProt P07564
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