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Thermostabilised adenosine A2A receptor in complex with 4-(3-amino-5- phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
Analyse Thermostabilised adenosine A2A receptor in complex with 4-(3-amino-5… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UZC
- Type
- protein
- Length
- 291 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenosine A2A receptor
- UniProt
- P29274
- Ligands
- T4E
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 82% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenosine A2A receptor | protein | 291 | 82% helix, 2% strand | P29274 |
Ligands and binding sites
- T4E · 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 347 | 0.73 | 0.84 | 43 | T4E |
| 2 | 184 | 0.59 | 0.81 | 25 | empty |
| 3 | 62 | 0.39 | 0.79 | 15 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29274
- Elsewhere: RCSB PDB 3UZC · PDBe 3UZC · UniProt P29274
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